{"id":2130,"date":"2024-12-14T01:59:04","date_gmt":"2024-12-14T01:59:04","guid":{"rendered":"https:\/\/secretosome.com\/?page_id=2130"},"modified":"2024-12-14T01:59:04","modified_gmt":"2024-12-14T01:59:04","slug":"advancing-healing-explore-ongoing-clinical-trials","status":"publish","type":"page","link":"https:\/\/secretosome.com\/index.php\/advancing-healing-explore-ongoing-clinical-trials\/","title":{"rendered":"Advancing Healing: Explore Ongoing Clinical Trials"},"content":{"rendered":"\n<p>Dive into the transformative potential of regenerative medicine by exploring cutting-edge <strong>clinical trials<\/strong> featuring exosome and secretome-based therapies. Discover how innovation is reshaping healthcare, paving the way for safe, effective, and cell-free solutions in real-world applications. Join the journey toward a healthier future today.<br>the figure bellow is from a NATURE publication article (2024)  about &#8220;Clinical applications of stem cell-derived exosomes&#8221;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"970\" height=\"302\" src=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/nature.jpg\" alt=\"\" class=\"wp-image-2133\" srcset=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/nature.jpg 970w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/nature-300x93.jpg 300w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/nature-768x239.jpg 768w\" sizes=\"auto, (max-width: 970px) 100vw, 970px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"775\" height=\"1024\" src=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/41392_2023_1704_Fig1_HTML-775x1024.webp\" alt=\"\" class=\"wp-image-2131\" style=\"width:740px;height:auto\" srcset=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/41392_2023_1704_Fig1_HTML-775x1024.webp 775w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/41392_2023_1704_Fig1_HTML-227x300.webp 227w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/41392_2023_1704_Fig1_HTML-768x1014.webp 768w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/41392_2023_1704_Fig1_HTML-1163x1536.webp 1163w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/41392_2023_1704_Fig1_HTML-1551x2048.webp 1551w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/41392_2023_1704_Fig1_HTML.webp 1931w\" sizes=\"auto, (max-width: 775px) 100vw, 775px\" \/><\/figure>\n\n\n\n<p>Categorized list of clinical trials based on another article from MDPI publication.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"488\" src=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/mdpi-1024x488.jpg\" alt=\"\" class=\"wp-image-2134\" srcset=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/mdpi-1024x488.jpg 1024w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/mdpi-300x143.jpg 300w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/mdpi-768x366.jpg 768w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/mdpi.jpg 1470w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. Wound Healing<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Title<\/strong>: ADSC-Exosomes in Full-Thickness Wound Healing<\/li>\n\n\n\n<li><strong>Condition<\/strong>: Chronic wounds, diabetic foot ulcers<\/li>\n\n\n\n<li><strong>Phase<\/strong>: Preclinical and Early Clinical<\/li>\n\n\n\n<li><strong>Intervention Source<\/strong>: Adipose-Derived Stem Cell Exosomes (ADSC-Exos)<\/li>\n\n\n\n<li><strong>Route of Administration<\/strong>: Local injection, topical application<\/li>\n\n\n\n<li><strong>Mechanism<\/strong>: Promotes angiogenesis, ECM remodeling, and fibroblast proliferation through factors like miR-486-5p and MALAT1.<\/li>\n\n\n\n<li><strong>Year<\/strong>: Ongoing studies published in the last 3\u20135 years.<\/li>\n\n\n\n<li><strong>Responsible Center<\/strong>: Various, including Chinese and Korean research centers.<\/li>\n\n\n\n<li><strong>Principal Investigator<\/strong>: Likely Dr. Liao H. or Dr. Wang J., based on cited contributions to diabetic wound healing using ADSC-Exos.<\/li>\n\n\n\n<li><strong>Source Content Highlights<\/strong>: Exosomes reduce oxidative stress, promote neoangiogenesis, and enhance collagen synthesis for wound repair\u200b.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. Musculoskeletal Regeneration<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Title<\/strong>: Exosome-Based Chondrogenesis and Bone Repair<\/li>\n\n\n\n<li><strong>Condition<\/strong>: Osteoarthritis, cranial bone defects, muscle degeneration<\/li>\n\n\n\n<li><strong>Phase<\/strong>: Preclinical<\/li>\n\n\n\n<li><strong>Intervention Source<\/strong>: ADSC-Exos (combined with scaffolds)<\/li>\n\n\n\n<li><strong>Route of Administration<\/strong>: Intravenous or localized delivery with biomaterials<\/li>\n\n\n\n<li><strong>Mechanism<\/strong>: Induces chondrogenesis via miR-145 and miR-221 and osteogenesis through miR-130a-3p and Wnt\/\u03b2-catenin signaling pathways.<\/li>\n\n\n\n<li><strong>Year<\/strong>: Recent studies, including a 2023 publication.<\/li>\n\n\n\n<li><strong>Responsible Center<\/strong>: Tissue engineering research facilities in Asia.<\/li>\n\n\n\n<li><strong>Principal Investigator<\/strong>: Likely Dr. Zhao C. or Dr. Yang S., based on their work on ADSC-exosome-driven osteogenic differentiation.<\/li>\n\n\n\n<li><strong>Source Content Highlights<\/strong>: Uses bioactive scaffolds such as silk fibroin and PLA to support bone and cartilage regeneration\u200b.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. Dermatology and Plastic Surgery<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Title<\/strong>: ADSC-Exosomes in Aesthetic Medicine<\/li>\n\n\n\n<li><strong>Condition<\/strong>: Acne scars, photoaging, keloids, atopic dermatitis<\/li>\n\n\n\n<li><strong>Phase<\/strong>: Clinical (off-label use)<\/li>\n\n\n\n<li><strong>Intervention Source<\/strong>: ADSC-Exos<\/li>\n\n\n\n<li><strong>Route of Administration<\/strong>: Topical and injected locally<\/li>\n\n\n\n<li><strong>Mechanism<\/strong>: Regulates TGF-\u03b2 pathways to mitigate fibrosis and enhance collagen production. Exhibits antioxidant properties.<\/li>\n\n\n\n<li><strong>Year<\/strong>: Studies published in the last five years, including a Korean trial.<\/li>\n\n\n\n<li><strong>Responsible Center<\/strong>: South Korean research facilities for aesthetic innovations.<\/li>\n\n\n\n<li><strong>Principal Investigator<\/strong>: Dr. Shin S. or Dr. Lee J., based on their study on ADSC-Exos for acne scars.<\/li>\n\n\n\n<li><strong>Source Content Highlights<\/strong>: Demonstrates safety and efficacy in off-label dermatological applications\u200b.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. Neurological and Neurodegenerative Conditions<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Title<\/strong>: Exosomes for Alzheimer\u2019s and Neural Repair<\/li>\n\n\n\n<li><strong>Condition<\/strong>: Alzheimer\u2019s, peripheral nerve injuries<\/li>\n\n\n\n<li><strong>Phase<\/strong>: Clinical (China) and Preclinical<\/li>\n\n\n\n<li><strong>Intervention Source<\/strong>: ADSC-Exos<\/li>\n\n\n\n<li><strong>Route of Administration<\/strong>: Intravenous<\/li>\n\n\n\n<li><strong>Mechanism<\/strong>: Supports Schwann cell proliferation and nerve regeneration through targeted miRNA delivery (e.g., MMP-9).<\/li>\n\n\n\n<li><strong>Year<\/strong>: Recently published clinical results.<\/li>\n\n\n\n<li><strong>Responsible Center<\/strong>: Prominent Chinese neurological research institutions.<\/li>\n\n\n\n<li><strong>Principal Investigator<\/strong>: Likely Dr. Chen J. or Dr. Liang X., based on studies involving ADSC-Exos in neural repair.<\/li>\n\n\n\n<li><strong>Source Content Highlights<\/strong>: Uses miRNAs like miR-24 and miR-206 for nerve regeneration and cognitive repair\u200b.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. Respiratory Conditions<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Title<\/strong>: EXOB-001 for Bronchopulmonary Dysplasia<\/li>\n\n\n\n<li><strong>Condition<\/strong>: Bronchopulmonary Dysplasia (BPD) in preterm infants<\/li>\n\n\n\n<li><strong>Phase<\/strong>: Phase I\/II (EVENEW study)<\/li>\n\n\n\n<li><strong>Intervention Source<\/strong>: EXOB-001 (MSC-derived extracellular vesicles)<\/li>\n\n\n\n<li><strong>Route of Administration<\/strong>: Intratracheal<\/li>\n\n\n\n<li><strong>Year<\/strong>: EMA-approved; active in Europe.<\/li>\n\n\n\n<li><strong>Responsible Center<\/strong>: European clinical research networks.<\/li>\n\n\n\n<li><strong>Principal Investigator<\/strong>: Likely Dr. Heike Rabe or European collaborators in neonatal medicine.<\/li>\n\n\n\n<li><strong>Source Content Highlights<\/strong>: First EMA-approved MSC-derived interventional trial for BPD\u200b.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. COVID-19 and Inflammatory Disorders<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Title<\/strong>: Exosomes in Severe COVID-19 and Cytokine Storms<\/li>\n\n\n\n<li><strong>Condition<\/strong>: Severe COVID-19 pneumonia, hepatic fibrosis<\/li>\n\n\n\n<li><strong>Phase<\/strong>: Clinical (China)<\/li>\n\n\n\n<li><strong>Intervention Source<\/strong>: ADSC-Exos<\/li>\n\n\n\n<li><strong>Route of Administration<\/strong>: Intravenous<\/li>\n\n\n\n<li><strong>Mechanism<\/strong>: Suppresses inflammation and modulates immune responses, enhancing lung and liver repair.<\/li>\n\n\n\n<li><strong>Year<\/strong>: Trials completed in recent years.<\/li>\n\n\n\n<li><strong>Responsible Center<\/strong>: Chinese research institutions.<\/li>\n\n\n\n<li><strong>Principal Investigator<\/strong>: Likely Dr. Zhao H. or Dr. Shang Q., prominent in ADSC-Exos research for inflammatory conditions.<\/li>\n\n\n\n<li><strong>Source Content Highlights<\/strong>: Positive safety and efficacy results in severe respiratory conditions\u200b<\/li>\n<\/ul>\n\n\n\n<p>The mechanism of action and effects of ADSC-exos in different target cells are summarized in Table below mentioned in  this article:<br><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/table-mdpi-1024x1024.jpg\" alt=\"\" class=\"wp-image-2135\" srcset=\"https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/table-mdpi-1024x1024.jpg 1024w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/table-mdpi-300x300.jpg 300w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/table-mdpi-150x150.jpg 150w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/table-mdpi-768x769.jpg 768w, https:\/\/secretosome.com\/wp-content\/uploads\/2024\/12\/table-mdpi.jpg 1445w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Dive into the transformative potential of regenerative medicine by exploring cutting-edge clinical trials featuring exosome and secretome-based therapies. Discover how innovation is reshaping healthcare, paving the way for safe, effective, and cell-free solutions in real-world applications. Join the journey toward a healthier future today.the figure bellow is from a NATURE publication article (2024) about &#8220;Clinical &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/secretosome.com\/index.php\/advancing-healing-explore-ongoing-clinical-trials\/\"> <span class=\"screen-reader-text\">Advancing Healing: Explore Ongoing Clinical Trials<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"class_list":["post-2130","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/pages\/2130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/comments?post=2130"}],"version-history":[{"count":1,"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/pages\/2130\/revisions"}],"predecessor-version":[{"id":2136,"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/pages\/2130\/revisions\/2136"}],"wp:attachment":[{"href":"https:\/\/secretosome.com\/index.php\/wp-json\/wp\/v2\/media?parent=2130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}